The lung mycobiome in the next-generation sequencing era

Laura Tipton, Elodie Ghedin, Alison Morris

Research output: Contribution to journalReview articlepeer-review

Abstract

The fungi that reside in the human lungs represent an understudied, but medically relevant comm-unity. From the few studies published on the lung mycobiome, we find that there are fungi in both the healthy and diseased respiratory tract, that these fungi vary widely between individuals, and that there is a trend toward lower fungal diversity among individuals with disease. This review discusses the few studies of the lung mycobiome and details the challenges that accompany lung mycobiome studies. These challenges include sample collection and processing, sequence amplification and processing, and a history of multiple names for species. Some challenges may never be solved, but others can be solved with more data and additional studies of the lung mycobiome.

Original languageEnglish (US)
Pages (from-to)334-341
Number of pages8
JournalVirulence
Volume8
Issue number3
DOIs
StatePublished - Apr 3 2017

Keywords

  • fungi
  • lung
  • mycobiome
  • next-generation sequencing
  • respiratory tract

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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