@article{9c3357fd7b8f4d12a58a39bd9639a513,
title = "The Microbiota-Gut-Brain Axis: From Motility to Mood",
abstract = "The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and extrinsic factors influence signaling along this axis, modulating the function of both the enteric and central nervous systems. More recently the role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established. In this review, we highlight the role of this axis in modulating enteric and central nervous system function and how this may impact disorders such as irritable bowel syndrome and disorders of mood and affect. We examine the overlapping biological constructs that underpin these disorders with a special emphasis on the neurotransmitter serotonin, which plays a key role in both the gastrointestinal tract and in the brain. Overall, it is clear that although animal studies have shown much promise, more progress is necessary before these findings can be translated for diagnostic and therapeutic benefit in patient populations.",
keywords = "Brain Gut Axis, Irritable Bowel Syndrome, Microbiota-Gut-Brain Axis, Mood Disorders, Motility",
author = "Margolis, {Kara G.} and Cryan, {John F.} and Mayer, {Emeran A.}",
note = "Funding Information: Funding This research was supported by grants from the National Institutes of Health : RO1 NS015547 (K.G.M.) and R01 DK048351 (E.A.M.); the Department of Defense: PR160365 (K.G.M.); Science Foundation Ireland : SFI/12/RC/ 2273_P2 (J.F.C.); the Saks Kavanaugh Foundation (J.F.C.); and the EU H2020 project DLV-848228 DISCOvERIE (development, diagnosis and prevention of gender-related somatic and mental comorbidities in irritable bowel syndrome in Europe) (J.F.C.). Funding Information: Conflicts of interest Kara G. Margolis has been a consultant for Takeda. John F. Cryan has been an invited speaker at meetings organized by Yakult, Alkermes, Ordesa & Alimentary Health, has been a consultant for Alkermes & Nestle, and has received research funding from Mead Johnson, Cremo, Nutricia, DuPont, Pharmavite, & 4D Pharma. Emeran A. Mayer is a scientific advisory board member of Danone, Axial Biotherapeutics, Viome, Amare, Mahana Therapeutics, Pendulum, Bloom Biosciences, and APC Microbiome Ireland.Funding This research was supported by grants from the National Institutes of Health: RO1 NS015547 (K.G.M.) and R01 DK048351 (E.A.M.); the Department of Defense: PR160365 (K.G.M.); Science Foundation Ireland: SFI/12/RC/ 2273_P2 (J.F.C.); the Saks Kavanaugh Foundation (J.F.C.); and the EU H2020 project DLV-848228 DISCOvERIE (development, diagnosis and prevention of gender-related somatic and mental comorbidities in irritable bowel syndrome in Europe) (J.F.C.). Funding Information: Conflicts of interest Kara G. Margolis has been a consultant for Takeda. John F. Cryan has been an invited speaker at meetings organized by Yakult, Alkermes, Ordesa & Alimentary Health, has been a consultant for Alkermes & Nestle, and has received research funding from Mead Johnson , Cremo , Nutricia , DuPont , Pharmavite, & 4D Pharma. Emeran A. Mayer is a scientific advisory board member of Danone, Axial Biotherapeutics, Viome, Amare, Mahana Therapeutics, Pendulum, Bloom Biosciences, and APC Microbiome Ireland. Publisher Copyright: {\textcopyright} 2021 AGA Institute",
year = "2021",
month = apr,
doi = "10.1053/j.gastro.2020.10.066",
language = "English (US)",
volume = "160",
pages = "1486--1501",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "5",
}