TY - JOUR
T1 - The mitochondrial protein import pathway
T2 - Are precursors imported through membrane channels?
AU - Jensen, Robert E.
AU - Kinnally, Kathleen W.
N1 - Funding Information:
We thank Carolyn Machamer, Alison Davis, and Oliver Kerscher for careful reading of the manuscript and for helpful discussions. We also thank Oliver Kerscher for the preparation of Fig. 3 (and the cover illustration). This work was supported by Grant R01-GM46803 from the United States Public Health Service to REJ, and by National Science Foundation Grant MCB9117658toKWK.
PY - 1997
Y1 - 1997
N2 - Mitochondrial biogenesis requires the import of hundreds of different proteins from the cytosol. Protein import into mitochondria is a multistep pathway that includes recognition of precursor proteins by machinery both in the cytoplasm and on the mitochondrial surface, translocation of the precursor across one or both mitochondrial membranes, and folding of the protein after its import into the organelle. Over the past several years, many components of the import machinery have been identified using both biochemical and genetic methods. Recently, significant progress has been made determining the function of some of these import proteins. One purpose of this minireview is to summarize our current understanding of the import pathway, and to introduce the topics of the minireviews that will follow. The other goal of this minireview is to discuss recent findings suggesting that proteins are translocated across both the mitochondrial inner and outer membranes through aqueous channels.
AB - Mitochondrial biogenesis requires the import of hundreds of different proteins from the cytosol. Protein import into mitochondria is a multistep pathway that includes recognition of precursor proteins by machinery both in the cytoplasm and on the mitochondrial surface, translocation of the precursor across one or both mitochondrial membranes, and folding of the protein after its import into the organelle. Over the past several years, many components of the import machinery have been identified using both biochemical and genetic methods. Recently, significant progress has been made determining the function of some of these import proteins. One purpose of this minireview is to summarize our current understanding of the import pathway, and to introduce the topics of the minireviews that will follow. The other goal of this minireview is to discuss recent findings suggesting that proteins are translocated across both the mitochondrial inner and outer membranes through aqueous channels.
KW - MCC
KW - Mitochondria
KW - PSC
KW - import pathway
KW - membrane channels
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U2 - 10.1023/A:1022470303365
DO - 10.1023/A:1022470303365
M3 - Review article
C2 - 9067796
AN - SCOPUS:0031042952
SN - 0145-479X
VL - 29
SP - 3
EP - 10
JO - Journal of Bioenergetics and Biomembranes
JF - Journal of Bioenergetics and Biomembranes
IS - 1
ER -