The molecular basis of reactive amyloidosis

Shoshana Yakar; Avi Livneh; Batia Kaplan; Mordechai Pras

doi:10.1016/S0049-0172(95)80035-2

The molecular basis of reactive amyloidosis

Shoshana Yakar, Avi Livneh, Batia Kaplan, Mordechai Pras

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Reactive amyloidosis is a disease occurring in patients suffering from chronicinfections, inflammation, and certain malignant conditions that are characterized by a considerable elevation of the acute phase reactant serum amyloid A (SAA). It is defined by the presence of extracellular deposits of fibrillar material containing amyloid A (AA) as its main component. AA is an 8.5-kd protein structurally identical to the NH₂-terminal of the acute phase reactant SAA. SAA consists of a group of evolutionally conserved amphipathic proteins, encoded by a large number of genes and produced abundantly during inflammation, all suggesting an important role, probably of a neutralizing (anti-inflammatory) nature. An analysis of various aspects of SAA provides no clues to the mechanism of amyloid production, its occurrence in only selected individuals, and its preferential relationship to one isotype of SAA. Until more data is available, the present view on AA amyloidogenesis remains hypothetical.

Original language	English (US)
Pages (from-to)	255-261
Number of pages	7
Journal	Seminars in Arthritis and Rheumatism
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/S0049-0172(95)80035-2
State	Published - Feb 1995

Keywords

Reactive amyloidosis
amyloid protein A
serum amyloid A

ASJC Scopus subject areas

Rheumatology
Anesthesiology and Pain Medicine

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10.1016/S0049-0172(95)80035-2

Cite this

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title = "The molecular basis of reactive amyloidosis",

abstract = "Reactive amyloidosis is a disease occurring in patients suffering from chronicinfections, inflammation, and certain malignant conditions that are characterized by a considerable elevation of the acute phase reactant serum amyloid A (SAA). It is defined by the presence of extracellular deposits of fibrillar material containing amyloid A (AA) as its main component. AA is an 8.5-kd protein structurally identical to the NH2-terminal of the acute phase reactant SAA. SAA consists of a group of evolutionally conserved amphipathic proteins, encoded by a large number of genes and produced abundantly during inflammation, all suggesting an important role, probably of a neutralizing (anti-inflammatory) nature. An analysis of various aspects of SAA provides no clues to the mechanism of amyloid production, its occurrence in only selected individuals, and its preferential relationship to one isotype of SAA. Until more data is available, the present view on AA amyloidogenesis remains hypothetical.",

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AU - Livneh, Avi

AU - Kaplan, Batia

AU - Pras, Mordechai

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N2 - Reactive amyloidosis is a disease occurring in patients suffering from chronicinfections, inflammation, and certain malignant conditions that are characterized by a considerable elevation of the acute phase reactant serum amyloid A (SAA). It is defined by the presence of extracellular deposits of fibrillar material containing amyloid A (AA) as its main component. AA is an 8.5-kd protein structurally identical to the NH2-terminal of the acute phase reactant SAA. SAA consists of a group of evolutionally conserved amphipathic proteins, encoded by a large number of genes and produced abundantly during inflammation, all suggesting an important role, probably of a neutralizing (anti-inflammatory) nature. An analysis of various aspects of SAA provides no clues to the mechanism of amyloid production, its occurrence in only selected individuals, and its preferential relationship to one isotype of SAA. Until more data is available, the present view on AA amyloidogenesis remains hypothetical.

AB - Reactive amyloidosis is a disease occurring in patients suffering from chronicinfections, inflammation, and certain malignant conditions that are characterized by a considerable elevation of the acute phase reactant serum amyloid A (SAA). It is defined by the presence of extracellular deposits of fibrillar material containing amyloid A (AA) as its main component. AA is an 8.5-kd protein structurally identical to the NH2-terminal of the acute phase reactant SAA. SAA consists of a group of evolutionally conserved amphipathic proteins, encoded by a large number of genes and produced abundantly during inflammation, all suggesting an important role, probably of a neutralizing (anti-inflammatory) nature. An analysis of various aspects of SAA provides no clues to the mechanism of amyloid production, its occurrence in only selected individuals, and its preferential relationship to one isotype of SAA. Until more data is available, the present view on AA amyloidogenesis remains hypothetical.

KW - Reactive amyloidosis

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The molecular basis of reactive amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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