TY - JOUR
T1 - The mycobiome-immune axis
T2 - The next frontier in pancreatic cancer
AU - Li, Xin
AU - Saxena, Deepak
N1 - Publisher Copyright:
Copyright © 2022 Elsevier Inc. All rights reserved.
PY - 2022/2/14
Y1 - 2022/2/14
N2 - In this issue of Cancer Cell, Aftab et al. identify a pro-inflammatory cytokine, IL-33, that is released as a chemoattractant for type 2 immune cells in response to the intratumoral mycobiome. Depletion of fungi or deletion of IL-33 in cancer cells significantly decreases pancreatic ductal adenocarcinoma (PDAC) tumor progression and increases survival.
AB - In this issue of Cancer Cell, Aftab et al. identify a pro-inflammatory cytokine, IL-33, that is released as a chemoattractant for type 2 immune cells in response to the intratumoral mycobiome. Depletion of fungi or deletion of IL-33 in cancer cells significantly decreases pancreatic ductal adenocarcinoma (PDAC) tumor progression and increases survival.
UR - http://www.scopus.com/inward/record.url?scp=85124679386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85124679386&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2022.01.009
DO - 10.1016/j.ccell.2022.01.009
M3 - Comment/debate
C2 - 35167821
AN - SCOPUS:85124679386
SN - 1535-6108
VL - 40
SP - 120
EP - 122
JO - Cancer Cell
JF - Cancer Cell
IS - 2
ER -