The Myth of 0.9% Saline: Neither Normal nor Physiological

Leon Chen

Research output: Contribution to journalArticlepeer-review


Normal saline is the crystalloid of choice for fluid resuscitation with its utility born out of the cholera epidemic of 1832. However, its ubiquitous usage is being challenged because of a growing body of evidence suggesting that a large volume infusion of normal saline does in fact have deleterious effects on multiple body systems. Careful considerations should be given to the physiological effects of using large amounts of normal saline as one would with another pharmacological agents.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalCritical care nursing quarterly
Issue number4
StatePublished - Sep 7 2015


  • crystalloids
  • fluid resuscitation
  • normal saline
  • physiological effects

ASJC Scopus subject areas

  • Critical Care


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