The nature of amide ligation to the metal sites of FeMoco

M. Anton Walters; Stephen K. Chapman; William H. Orme-Johnson

doi:10.1016/S0277-5387(00)84964-5

The nature of amide ligation to the metal sites of FeMoco

M. Anton Walters, Stephen K. Chapman, William H. Orme-Johnson

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The nature of the ligation of N-methylformamide (NMF) to the metal sites of FeMoco has been investigated. The IR spectrum of FeMoco in NMF shows an intense band at 1600 cm^-1 which we assign to the v(CO) stretch of ligated NMF. This frequency is characteristic of N-deprotonated amide ligands, indicating that NMF ligation to FeMoco is predominantly through nitrogen. Hence NMF behaves as an anionic ligand. The importance of the amide functionality for FeMoco extraction has been further examined and a new extracting agent, 2-pyrrolidinone, has been employed. We hypothesize that, in the MoFe-protein, the primary coordination of the cofactor is via deprotonated backbone amide ligands.

Original language	English (US)
Pages (from-to)	561-565
Number of pages	5
Journal	Polyhedron
Volume	5
Issue number	1-2
DOIs	https://doi.org/10.1016/S0277-5387(00)84964-5
State	Published - 1986

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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title = "The nature of amide ligation to the metal sites of FeMoco",

abstract = "The nature of the ligation of N-methylformamide (NMF) to the metal sites of FeMoco has been investigated. The IR spectrum of FeMoco in NMF shows an intense band at 1600 cm-1 which we assign to the v(CO) stretch of ligated NMF. This frequency is characteristic of N-deprotonated amide ligands, indicating that NMF ligation to FeMoco is predominantly through nitrogen. Hence NMF behaves as an anionic ligand. The importance of the amide functionality for FeMoco extraction has been further examined and a new extracting agent, 2-pyrrolidinone, has been employed. We hypothesize that, in the MoFe-protein, the primary coordination of the cofactor is via deprotonated backbone amide ligands.",

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AU - Walters, M. Anton

AU - Chapman, Stephen K.

AU - Orme-Johnson, William H.

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N2 - The nature of the ligation of N-methylformamide (NMF) to the metal sites of FeMoco has been investigated. The IR spectrum of FeMoco in NMF shows an intense band at 1600 cm-1 which we assign to the v(CO) stretch of ligated NMF. This frequency is characteristic of N-deprotonated amide ligands, indicating that NMF ligation to FeMoco is predominantly through nitrogen. Hence NMF behaves as an anionic ligand. The importance of the amide functionality for FeMoco extraction has been further examined and a new extracting agent, 2-pyrrolidinone, has been employed. We hypothesize that, in the MoFe-protein, the primary coordination of the cofactor is via deprotonated backbone amide ligands.

AB - The nature of the ligation of N-methylformamide (NMF) to the metal sites of FeMoco has been investigated. The IR spectrum of FeMoco in NMF shows an intense band at 1600 cm-1 which we assign to the v(CO) stretch of ligated NMF. This frequency is characteristic of N-deprotonated amide ligands, indicating that NMF ligation to FeMoco is predominantly through nitrogen. Hence NMF behaves as an anionic ligand. The importance of the amide functionality for FeMoco extraction has been further examined and a new extracting agent, 2-pyrrolidinone, has been employed. We hypothesize that, in the MoFe-protein, the primary coordination of the cofactor is via deprotonated backbone amide ligands.

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The nature of amide ligation to the metal sites of FeMoco

Abstract

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