The neurobiological bases of memory formation: From physiological conditions to psychopathology

Reto Bisaz; Alessio Travaglia; Cristina M. Alberini

doi:10.1159/000363702

The neurobiological bases of memory formation: From physiological conditions to psychopathology

Reto Bisaz, Alessio Travaglia, Cristina M. Alberini

Neural Science

Research output: Contribution to journal › Article › peer-review

Abstract

The formation of long-term memories is a function necessary for an adaptive survival. In the last two decades, great progress has been made in the understanding of the biological bases of memory formation. The identification of mechanisms necessary for memory consolidation and reconsolidation, the processes by which the posttraining and postretrieval fragile memory traces become stronger and insensitive to disruption, has indicated new approaches for investigating and treating psychopathologies. In this review, we will discuss some key biological mechanisms found to be critical for memory consolidation and strengthening, the role/s and mechanisms of memory reconsolidation, and how the interference with consolidation and/or reconsolidation can modulate the retention and/or storage of memories that are linked to psychopathologies.

Original language	English (US)
Pages (from-to)	347-356
Number of pages	10
Journal	Psychopathology
Volume	47
Issue number	6
DOIs	https://doi.org/10.1159/000363702
State	Published - Apr 17 2014

Keywords

Consolidation
Memory
Molecular mechanisms
Posttraumatic stress disorder
Reconsolidation
Retrieval
Stress

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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10.1159/000363702

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The neurobiological bases of memory formation: From physiological conditions to psychopathology

Abstract

Keywords

ASJC Scopus subject areas

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