The neurobiology of cancer pain

Research output: Contribution to journalArticlepeer-review


The global burden of cancer pain is enormous and opioids, despite their side effects, remain the primary therapeutic approach. The cause of cancer pain is unknown. Mechanisms driving cancer pain differ from those mechanisms responsible for inflammatory and neuropathic pain. The prevailing hypothesis put forward to explain cancer pain posits that cancers generate and secrete mediators which sensitize and activate primary afferent nociceptors in the cancer microenvironment. Moreover, cancers induce neurochemical reorganization of the spinal cord, which contributes to spontaneous activity and enhanced responsiveness. The purpose of this review, which covers clinical and preclinical studies, is to highlight those peripheral and central mechanisms responsible for cancer pain. The challenges facing neuroscientists and clinicians studying and ultimately treating cancer pain are discussed.

Original languageEnglish (US)
Pages (from-to)546-562
Number of pages17
Issue number5
StatePublished - Oct 1 2014


  • cancer
  • cancer pain
  • pain
  • sensory system
  • tumor

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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