The Neurobiology of Decision: Consensus and Controversy

Joseph W. Kable; Paul W. Glimcher

doi:10.1016/j.neuron.2009.09.003

The Neurobiology of Decision: Consensus and Controversy

Joseph W. Kable, Paul W. Glimcher

Neural Science

Research output: Contribution to journal › Review article › peer-review

Abstract

We review and synthesize recent neurophysiological studies of decision making in humans and nonhuman primates. From these studies, the basic outline of the neurobiological mechanism for primate choice is beginning to emerge. The identified mechanism is now known to include a multicomponent valuation stage, implemented in ventromedial prefrontal cortex and associated parts of striatum, and a choice stage, implemented in lateral prefrontal and parietal areas. Neurobiological studies of decision making are beginning to enhance our understanding of economic and social behavior as well as our understanding of significant health disorders where people's behavior plays a key role.

Original language	English (US)
Pages (from-to)	733-745
Number of pages	13
Journal	Neuron
Volume	63
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2009.09.003
State	Published - Sep 24 2009

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2009.09.003

Cite this

@article{7f6201e7f66f42df9b56f211f2348354,

title = "The Neurobiology of Decision: Consensus and Controversy",

abstract = "We review and synthesize recent neurophysiological studies of decision making in humans and nonhuman primates. From these studies, the basic outline of the neurobiological mechanism for primate choice is beginning to emerge. The identified mechanism is now known to include a multicomponent valuation stage, implemented in ventromedial prefrontal cortex and associated parts of striatum, and a choice stage, implemented in lateral prefrontal and parietal areas. Neurobiological studies of decision making are beginning to enhance our understanding of economic and social behavior as well as our understanding of significant health disorders where people's behavior plays a key role.",

author = "Kable, {Joseph W.} and Glimcher, {Paul W.}",

note = "Funding Information: We thank N. Senecal and J. Stump for their comments on a previous version of this manuscript. P.W.G. is supported by grants from the National Institutes of Health (R01-EY010536 and R01-NS054775). ",

year = "2009",

month = sep,

day = "24",

doi = "10.1016/j.neuron.2009.09.003",

language = "English (US)",

volume = "63",

pages = "733--745",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - The Neurobiology of Decision

T2 - Consensus and Controversy

AU - Kable, Joseph W.

AU - Glimcher, Paul W.

N1 - Funding Information: We thank N. Senecal and J. Stump for their comments on a previous version of this manuscript. P.W.G. is supported by grants from the National Institutes of Health (R01-EY010536 and R01-NS054775).

PY - 2009/9/24

Y1 - 2009/9/24

N2 - We review and synthesize recent neurophysiological studies of decision making in humans and nonhuman primates. From these studies, the basic outline of the neurobiological mechanism for primate choice is beginning to emerge. The identified mechanism is now known to include a multicomponent valuation stage, implemented in ventromedial prefrontal cortex and associated parts of striatum, and a choice stage, implemented in lateral prefrontal and parietal areas. Neurobiological studies of decision making are beginning to enhance our understanding of economic and social behavior as well as our understanding of significant health disorders where people's behavior plays a key role.

AB - We review and synthesize recent neurophysiological studies of decision making in humans and nonhuman primates. From these studies, the basic outline of the neurobiological mechanism for primate choice is beginning to emerge. The identified mechanism is now known to include a multicomponent valuation stage, implemented in ventromedial prefrontal cortex and associated parts of striatum, and a choice stage, implemented in lateral prefrontal and parietal areas. Neurobiological studies of decision making are beginning to enhance our understanding of economic and social behavior as well as our understanding of significant health disorders where people's behavior plays a key role.

UR - http://www.scopus.com/inward/record.url?scp=70349138795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349138795&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2009.09.003

DO - 10.1016/j.neuron.2009.09.003

M3 - Review article

C2 - 19778504

AN - SCOPUS:70349138795

SN - 0896-6273

VL - 63

SP - 733

EP - 745

JO - Neuron

JF - Neuron

IS - 6

ER -

The Neurobiology of Decision: Consensus and Controversy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this