The notochord gene regulatory network in chordate evolution: Conservation and divergence from Ciona to vertebrates

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The notochord is a structure required for support and patterning of all chordate embryos, from sea squirts to humans. An increasing amount of information on notochord development and on the molecular strategies that ensure its proper morphogenesis has been gleaned through studies in the sea squirt Ciona. This invertebrate chordate offers a fortunate combination of experimental advantages, ranging from translucent, fast-developing embryos to a compact genome and impressive biomolecular resources. These assets have enabled the rapid identification of numerous notochord genes and cis-regulatory regions, and provide a rather unique opportunity to reconstruct the gene regulatory network that controls the formation of this developmental and evolutionary chordate landmark. This chapter summarizes the morphogenetic milestones that punctuate notochord formation in Ciona, their molecular effectors, and the current knowledge of the gene regulatory network that ensures the accurate spatial and temporal orchestration of these processes.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages325-374
Number of pages50
DOIs
StatePublished - 2020

Publication series

NameCurrent Topics in Developmental Biology
Volume139
ISSN (Print)0070-2153

Keywords

  • Ascidian
  • Brachyury
  • Ciona
  • Enhancer
  • Gene expression
  • Gene regulatory network
  • Notochord
  • Transcription factor
  • cis-Regulatory module

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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  • Cite this

    Di Gregorio, A. (2020). The notochord gene regulatory network in chordate evolution: Conservation and divergence from Ciona to vertebrates. In Current Topics in Developmental Biology (pp. 325-374). (Current Topics in Developmental Biology; Vol. 139). Academic Press Inc.. https://doi.org/10.1016/bs.ctdb.2020.01.002