The organization and development of cortical interneuron presynaptic circuits are area specific

Gabrielle Pouchelon, Deepanjali Dwivedi, Yannick Bollmann, Chimuanya K. Agba, Qing Xu, Andrea M.C. Mirow, Sehyun Kim, Yanjie Qiu, Elaine Sevier, Kimberly D. Ritola, Rosa Cossart, Gord Fishell

Research output: Contribution to journalArticlepeer-review


Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory and cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are genetically invariant and are thought to form canonical circuits regardless of which area they are embedded in. Here, we investigate whether this is achieved through selective and systematic variations in their afferent connectivity during development. To this end, we examined the development of their inputs within distinct cortical areas. We find that interneuron afferents show little evidence of being globally stereotyped. Rather, each subtype displays characteristic regional connectivity and distinct developmental dynamics by which this connectivity is achieved. Moreover, afferents dynamically regulated during development are disrupted by early sensory deprivation and in a model of fragile X syndrome. These data provide a comprehensive map of interneuron afferents across cortical areas and reveal the logic by which these circuits are established during development.

Original languageEnglish (US)
Article number109993
JournalCell Reports
Issue number6
StatePublished - Nov 9 2021


  • ALM
  • GABAergic interneurons
  • cortical areas
  • development
  • fragile X syndrome
  • monosynaptic rabies tracing
  • sensory cortex
  • thalamocortical input

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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