@article{8a28ea1845734bae81833174ffe4e19c,
title = "The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria",
abstract = "In animals, PIWI-interacting RNAs (piRNAs) direct germline transposon silencing. Ge et al. now show that in Drosophila the RNA-binding ATPase protein Armitage uses ATP hydrolysis to selectively bind piRNA precursors, escorting them from the ping-pong piRNA-producing machinery in perinuclear nuage to the phased piRNA-producing pathway on mitochondria.",
keywords = "argonaute, ATP, DTME, helicase, immunoprecipitation, mass spectrometry, microscopy, mitochondrion, RNA-seq, small RNA",
author = "Ge, {Daniel Tianfang} and Wei Wang and Cindy Tipping and Ildar Gainetdinov and Zhiping Weng and Zamore, {Phillip D.}",
note = "Funding Information: We thank John Leszyk and Michelle Dubuke at the UMass Proteomics Core, Keith Reddig at the UMass Electron Microscopy Core, Christina Baer at the UMass Sanderson Center for Optical Experimentation, and Haiwei Mou, Cha San Koh, and members of the Zamore laboratory for help and discussions. This work was supported by NIH grants ( R37GM062862 to P.D.Z. and P01HD078253 to Z.W. and P.D.Z.). The UMass Electron Microscopy Core Facility is supported by grant S10RR027897 from the National Center for Research Resources . Funding Information: We thank John Leszyk and Michelle Dubuke at the UMass Proteomics Core, Keith Reddig at the UMass Electron Microscopy Core, Christina Baer at the UMass Sanderson Center for Optical Experimentation, and Haiwei Mou, Cha San Koh, and members of the Zamore laboratory for help and discussions. This work was supported by NIH grants (R37GM062862 to P.D.Z. and P01HD078253 to Z.W. and P.D.Z.). The UMass Electron Microscopy Core Facility is supported by grant S10RR027897 from the National Center for Research Resources. D.T.G. and P.D.Z. conceived the experiments. D.T.G. W.W. Z.W. and P.D.Z. designed the experiments. D.T.G. and C.T. performed the experiments. W.W. I.G. and D.T.G. analyzed the sequencing data. D.T.G. Z.W. and P.D.Z. wrote the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jun,
day = "6",
doi = "10.1016/j.molcel.2019.04.006",
language = "English (US)",
volume = "74",
pages = "982--995.e6",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "5",
}