The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

Daniel Tianfang Ge; Wei Wang; Cindy Tipping; Ildar Gainetdinov; Zhiping Weng; Phillip D. Zamore

doi:10.1016/j.molcel.2019.04.006

The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

Daniel Tianfang Ge, Wei Wang, Cindy Tipping, Ildar Gainetdinov, Zhiping Weng, Phillip D. Zamore

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

In animals, PIWI-interacting RNAs (piRNAs) direct germline transposon silencing. Ge et al. now show that in Drosophila the RNA-binding ATPase protein Armitage uses ATP hydrolysis to selectively bind piRNA precursors, escorting them from the ping-pong piRNA-producing machinery in perinuclear nuage to the phased piRNA-producing pathway on mitochondria.

Original language	English (US)
Pages (from-to)	982-995.e6
Journal	Molecular Cell
Volume	74
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2019.04.006
State	Published - Jun 6 2019

Keywords

ATP
DTME
RNA-seq
argonaute
helicase
immunoprecipitation
mass spectrometry
microscopy
mitochondrion
small RNA

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2019.04.006

Cite this

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title = "The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria",

abstract = "In animals, PIWI-interacting RNAs (piRNAs) direct germline transposon silencing. Ge et al. now show that in Drosophila the RNA-binding ATPase protein Armitage uses ATP hydrolysis to selectively bind piRNA precursors, escorting them from the ping-pong piRNA-producing machinery in perinuclear nuage to the phased piRNA-producing pathway on mitochondria.",

keywords = "ATP, DTME, RNA-seq, argonaute, helicase, immunoprecipitation, mass spectrometry, microscopy, mitochondrion, small RNA",

author = "Ge, {Daniel Tianfang} and Wei Wang and Cindy Tipping and Ildar Gainetdinov and Zhiping Weng and Zamore, {Phillip D.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.molcel.2019.04.006",

language = "English (US)",

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T1 - The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

AU - Ge, Daniel Tianfang

AU - Wang, Wei

AU - Tipping, Cindy

AU - Gainetdinov, Ildar

AU - Weng, Zhiping

AU - Zamore, Phillip D.

PY - 2019/6/6

Y1 - 2019/6/6

N2 - In animals, PIWI-interacting RNAs (piRNAs) direct germline transposon silencing. Ge et al. now show that in Drosophila the RNA-binding ATPase protein Armitage uses ATP hydrolysis to selectively bind piRNA precursors, escorting them from the ping-pong piRNA-producing machinery in perinuclear nuage to the phased piRNA-producing pathway on mitochondria.

AB - In animals, PIWI-interacting RNAs (piRNAs) direct germline transposon silencing. Ge et al. now show that in Drosophila the RNA-binding ATPase protein Armitage uses ATP hydrolysis to selectively bind piRNA precursors, escorting them from the ping-pong piRNA-producing machinery in perinuclear nuage to the phased piRNA-producing pathway on mitochondria.

KW - ATP

KW - DTME

KW - RNA-seq

KW - argonaute

KW - helicase

KW - immunoprecipitation

KW - mass spectrometry

KW - microscopy

KW - mitochondrion

KW - small RNA

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JO - Molecular Cell

JF - Molecular Cell

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ER -

The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

Abstract

Keywords

ASJC Scopus subject areas

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