The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation

Jonathan M. Bekisz, Christopher D. Lopez, Carmen Corciulo, Aranzazu Mediero, Paulo G. Coelho, Lukasz Witek, Roberto L. Flores, Bruce N. Cronstein

Research output: Contribution to journalReview article

Abstract

Adenosine receptor activation has been explored as a modulator of the inflammatory process that propagates osteoarthritis. It has been reported that cartilage has enhanced regenerative potential when influenced by adenosine receptor activation. As adenosine’s role in maintaining chondrocyte homeostasis at the cellular and molecular levels is explored, successful in vivo applications of adenosine delivery for cartilage repair continue to be reported. This review summarizes the role adenosine receptor ligation plays in chondrocyte homeostasis and regeneration of articular cartilage damaged in osteoarthritis. It also reports on all the modalities reported for delivery of adenosine through in vivo applications.

Original languageEnglish (US)
Pages (from-to)1135-1141
Number of pages7
JournalInflammation
Volume41
Issue number4
DOIs
StatePublished - Aug 1 2018

Keywords

  • cartilage
  • chondrocyte
  • regeneration
  • tissue engineering

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Bekisz, J. M., Lopez, C. D., Corciulo, C., Mediero, A., Coelho, P. G., Witek, L., Flores, R. L., & Cronstein, B. N. (2018). The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation. Inflammation, 41(4), 1135-1141. https://doi.org/10.1007/s10753-018-0781-z