Abstract
Peptide hormones and neurotransmitters play an essential role in regulation of cellular metabolism. Once released from an endocrine cell or nerve ending, peptides encounter membrane-bound and soluble peptidases. The peptidases inactivate peptides or form fragments with novel biologic activity. Therefore, peptidases must play a major role in homeostatic control, but this aspect of regulation has been a neglected area. This review examines the postsecretory metabolism of biologically active peptides in the brain and alimentary tract, 2 organs in which peptide regulation is of crucial importance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S27-34 |
| Journal | American Review of Respiratory Disease |
| Volume | 136 |
| Issue number | 6 Pt 2 |
| State | Published - Dec 1987 |
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine