The Role of Nuclear Actin in Genome Organization and Gene Expression Regulation During Differentiation

Syed Raza Mahmood, Nadine Hosny El Said, Piergiorgio Percipalle

Research output: Chapter in Book/Report/Conference proceedingChapter


In the cell nucleus, actin participates in numerous essential processes. Actin is involved in chromatin as part of specific ATP-dependent chromatin remodeling complexes and associates with the RNA polymerase machinery to regulate transcription at multiple levels. Emerging evidence has also shown that the nuclear actin pool controls the architecture of the mammalian genome playing an important role in its hierarchical organization into transcriptionally active and repressed compartments, contributing to the clustering of RNA polymerase II into transcriptional hubs. Here, we review the most recent literature and discuss how actin involvement in genome organization impacts the regulation of gene programs that are activated or repressed during differentiation and development. As in the cytoplasm, we propose that nuclear actin is involved in key nuclear tasks in complex with different types of actin-binding proteins that regulate actin function and bridge interactions between actin and various nuclear components.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages18
StatePublished - 2022

Publication series

NameResults and Problems in Cell Differentiation
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412


  • Chromatin remodeling
  • Differentiation
  • Epigenetics
  • Gene expression
  • Genome organization
  • Nuclear actin
  • Transcriptional regulation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'The Role of Nuclear Actin in Genome Organization and Gene Expression Regulation During Differentiation'. Together they form a unique fingerprint.

Cite this