TY - JOUR
T1 - The role of protein synthesis during the labile phases of memory
T2 - Revisiting the skepticism
AU - Alberini, Cristina M.
N1 - Funding Information:
Many thanks to Deanna Benson and Bob Blitzer for their helpful comments. Thanks to all the members of my lab for their invaluable contribution to the work discussed and for their helpful feedback on the manuscript and to Reginald Miller and the CCMS facility of Mount Sinai for technical support. The work included in this review was supported by the National Institute of Mental Health (R01 MH65635, R01 MH074736), National Institute of Drugs of Abuse (R21 CEBRA DA017672) and Hirschl Foundation to C.M.A.
PY - 2008/3
Y1 - 2008/3
N2 - Despite the fact that extensive evidence supports the view that phases of de novo protein synthesis are necessary for memory formation and maintenance, doubts are still raised. Skeptics generally argue that amnesia and the disruption of long-term synaptic plasticity are caused by "non-specific effects" of the reagents or approaches used to disrupt protein synthesis. This paper attempts to clarify some of these issues by reviewing, discussing and providing results addressing some of the major critiques that argue against the idea that de novo protein synthesis is necessary for the stabilization of long-term memory.
AB - Despite the fact that extensive evidence supports the view that phases of de novo protein synthesis are necessary for memory formation and maintenance, doubts are still raised. Skeptics generally argue that amnesia and the disruption of long-term synaptic plasticity are caused by "non-specific effects" of the reagents or approaches used to disrupt protein synthesis. This paper attempts to clarify some of these issues by reviewing, discussing and providing results addressing some of the major critiques that argue against the idea that de novo protein synthesis is necessary for the stabilization of long-term memory.
KW - Gene expression
KW - Memory consolidation
KW - Memory reconsolidation
KW - Protein synthesis inhibitor
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U2 - 10.1016/j.nlm.2007.08.007
DO - 10.1016/j.nlm.2007.08.007
M3 - Article
C2 - 17928243
AN - SCOPUS:39849094746
SN - 1074-7427
VL - 89
SP - 234
EP - 246
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
IS - 3
ER -