The role of protein synthesis during the labile phases of memory: Revisiting the skepticism

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Abstract

Despite the fact that extensive evidence supports the view that phases of de novo protein synthesis are necessary for memory formation and maintenance, doubts are still raised. Skeptics generally argue that amnesia and the disruption of long-term synaptic plasticity are caused by "non-specific effects" of the reagents or approaches used to disrupt protein synthesis. This paper attempts to clarify some of these issues by reviewing, discussing and providing results addressing some of the major critiques that argue against the idea that de novo protein synthesis is necessary for the stabilization of long-term memory.

Original languageEnglish (US)
Pages (from-to)234-246
Number of pages13
JournalNeurobiology of Learning and Memory
Volume89
Issue number3
DOIs
StatePublished - Mar 2008

Keywords

  • Gene expression
  • Memory consolidation
  • Memory reconsolidation
  • Protein synthesis inhibitor

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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