The role of substance abuse in HIV disease progression: Reconciling differences from laboratory and epidemiologic investigations

Farzana Kapadia, David Vlahov, Robert M. Donahoe, Gerald Friedland

Research output: Contribution to journalReview article

Abstract

From the onset of the HIV/AIDS epidemic, the use of licit and illicit drugs has been investigated for its potential impact on HIV disease progression. Findings from a large number of laboratory-based studies indicate that drug abuse may exacerbate HIV disease progression; however, epidemiological studies have shown mixed results. This article presents a review of findings from both laboratory-based and epidemiologic investigations. In addition, we provide a careful evaluation of methodological strengths and limitations inherent to both study designs in order to provide a more nuanced understanding of how these findings may complement one another.

Original languageEnglish (US)
Pages (from-to)1027-1034
Number of pages8
JournalClinical Infectious Diseases
Volume41
Issue number7
DOIs
StatePublished - Oct 1 2005

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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