The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models

Shoshana Yakar, Derek LeRoith, Pnina Brodt

Research output: Contribution to journalReview article

Abstract

Over the past two decades it has become widely appreciated that a relationship exists between the insulin-like growth factors (IGFs) and cancer. Many cancers have been shown to overexpress the IGF-I receptor and produce the ligands (IGF-I or IGF-II) and some combinations of the six IGF-binding proteins. With the recent demonstration by epidemiological studies that an elevated serum IGF-I level is associated with an increased relative risk of developing a number of epithelial cancers, interest has been sparked in this area of research with the possibility of targeting the IGF-I receptor in cancer treatment protocols. This review highlights many of the most relevant studies in this exciting area of research, focusing in particular on lessons learned from animal models of cancer.

Original languageEnglish (US)
Pages (from-to)407-420
Number of pages14
JournalCytokine and Growth Factor Reviews
Volume16
Issue number4-5
DOIs
StatePublished - Aug 1 2005

Keywords

  • Cancer
  • Insulin-like growth factor
  • Mouse models
  • Receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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