The role of the lateral nucleus of the amygdala in auditory fear conditioning

Hugh T. Blair, Karim Nader, Glenn E. Schafe, Elizabeth P. Bauer, Sarina M. Rodrigues, Joseph E. Ledoux

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction Classical fear conditioning is a form of associative learning in which subjects are trained to express fear responses to a neutral conditioned stimulus (CS) that is paired with an aversive unconditioned stimulus (US). As a result of such pairing, the CS comes to elicit behavioral, autonomic, and endocrine responses that are characteristically expressed in the presence of danger (Blanchard & Blanchard, 1969; Bolles & Fanselow, 1980; Smith et al., 1980). Fear conditioning has emerged as an especially useful behavioral model for investigating the neurobiological mechanisms of learning and memory, because fear memories are rapidly acquired and long-lasting, involve well-defined stimuli and responses, and depend upon similar neural circuits in different vertebrate species (see Davis & Lee, 1998; LeDoux, 2000; Maren, 1999; Rogan et al., 2001). In this chapter, we review studies that have investigated the role of the amygdala in fear learning. We argue that neural plasticity in the lateral amygdala is critical for storing memories of the association between the CS and US during fear conditioning, and discuss how learning and memory are achieved at the cellular or molecular level. Alternative views of amygdala contributions to fear conditioning are also considered. The amygdala and fear conditioning Fear learning depends critically upon the amygdala (Davis & Shi, 2000; Fendt & Fanselow, 1999; LeDoux, 1996, 2000), a cluster of nuclei in the brain’s temporal lobe that plays a key role in regulating emotions (Kluver & Bucy, 1939; LeDoux, 1996).

Original languageEnglish (US)
Title of host publicationTopics in Integrative Neuroscience
Subtitle of host publicationFrom Cells to Cognition
PublisherCambridge University Press
Pages299-325
Number of pages27
ISBN (Electronic)9780511541681
ISBN (Print)9780521869133
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Neuroscience(all)

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    Blair, H. T., Nader, K., Schafe, G. E., Bauer, E. P., Rodrigues, S. M., & Ledoux, J. E. (2008). The role of the lateral nucleus of the amygdala in auditory fear conditioning. In Topics in Integrative Neuroscience: From Cells to Cognition (pp. 299-325). Cambridge University Press. https://doi.org/10.1017/CBO9780511541681.016