Rol' topologicheskikh ogranicheniǐ v kinetike kollapsa gomopolimera i v samoorganizatsii biopolimerov.

Translated title of the contribution: The role of topological limitations in the kinetics of homopolymer collapse and self-assembly of biopolymers

A. I. Grosberg, S. K. Nechaev, E. I. Shakhnovich

    Research output: Contribution to journalArticle

    Abstract

    Fast collapse of a linear homopolymer after a spasmodic temperature decrease or deterioration of the solvent quality results in the initiation of folded nonequilibrium globule. The chain line in it is a fractal with the dimension mu less than or equal to 2 at small ranges and 3 at the large ones. This is provided by non-selfintersection of the chain and initiated therefore spatial segregation from each other at all the ranges of the chain regions, globulized each in itself. Further relaxation of the folded globule proceeds very slowly only at the expense of reptation (diffusion crawling) of the chain along itself, and results in the polymer knotting. The model of the folded globule permits explanation from a single viewpoint of a number of globular proteins properties. Predictions are formulated whose checking in a real or computer experiment should reveal the adequacy of our results.

    Translated title of the contributionThe role of topological limitations in the kinetics of homopolymer collapse and self-assembly of biopolymers
    Original languageRussian
    Pages (from-to)247-253
    Number of pages7
    JournalBiofizika
    Volume33
    Issue number2
    StatePublished - Mar 1988

    ASJC Scopus subject areas

    • Medicine(all)

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  • Cite this

    Grosberg, A. I., Nechaev, S. K., & Shakhnovich, E. I. (1988). Rol' topologicheskikh ogranicheniǐ v kinetike kollapsa gomopolimera i v samoorganizatsii biopolimerov. Biofizika, 33(2), 247-253.