The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association

Jacek Debiec, Lorenzo Diaz-Mataix, David E.A. Bush, Valérie Doyère, Joseph E. LeDoux

Research output: Contribution to journalArticlepeer-review

Abstract

In reconsolidation studies, memories are typically retrieved by an exposure to a single conditioned stimulus (CS). We have previously demonstrated that reconsolidation processes are CS-selective, suggesting that memories retrieved by the CS exposure are discrete and reconsolidate separately. Here, using a compound stimulus in which two distinct CSs are concomitantly paired with the same aversive unconditioned stimulus (US), we show in rats that reexposure to one of the components of the compound CS triggers extinction or reconsolidation of the other component. This suggests that the original training conditions play a critical role in memory retrieval and reconsolidation.

Original languageEnglish (US)
Pages (from-to)695-699
Number of pages5
JournalLearning and Memory
Volume20
Issue number12
DOIs
StatePublished - Dec 2013

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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