The single-cell eQTLGen consortium

M. G.P. van der Wijst, D. H. de Vries, H. E. Groot, G. Trynka, C. C. Hon, M. J. Bonder, O. Stegle, M. C. Nawijn, Y. Idaghdour, P. van der Harst, C. J. Ye, J. Powell, F. J. Theis, A. Mahfouz, M. Heinig, L. Franke

Research output: Contribution to journalArticle

Abstract

In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opportunities for mapping eQTLs across different cell types and in dynamic processes, many of which are obscured when using bulk methods. Rapid increase in throughput and reduction in cost per cell now allow this technology to be applied to large-scale population genetics studies. To fully leverage these emerging data resources, we have founded the single-cell eQTLGen consortium (sc-eQTLGen), aimed at pinpointing the cellular contexts in which disease-causing genetic variants affect gene expression. Here, we outline the goals, approach and potential utility of the sc-eQTLGen consortium. We also provide a set of study design considerations for future single-cell eQTL studies.

Original languageEnglish (US)
Article numbere52155
JournaleLife
Volume9
DOIs
StatePublished - Mar 2020

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The single-cell eQTLGen consortium'. Together they form a unique fingerprint.

  • Cite this

    van der Wijst, M. G. P., de Vries, D. H., Groot, H. E., Trynka, G., Hon, C. C., Bonder, M. J., Stegle, O., Nawijn, M. C., Idaghdour, Y., van der Harst, P., Ye, C. J., Powell, J., Theis, F. J., Mahfouz, A., Heinig, M., & Franke, L. (2020). The single-cell eQTLGen consortium. eLife, 9, [e52155]. https://doi.org/10.7554/eLife.52155