The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

Carrie Baker Brachmann; Joyce M. Sherman; Scott E. Devine; Elizabeth E. Cameron; Lorraine Pillus; Jef D. Boeke

doi:10.1101/gad.9.23.2888

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

Carrie Baker Brachmann, Joyce M. Sherman, Scott E. Devine, Elizabeth E. Cameron, Lorraine Pillus, Jef D. Boeke

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals. At least three HST genes can function in silencing; HST1 overexpression restores transcriptional silencing to a sir2 mutant and hst3 hst4 double mutants are defective in telomeric silencing. In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes.

Original language	English (US)
Pages (from-to)	2888-2902
Number of pages	15
Journal	Genes and Development
Volume	9
Issue number	23
DOIs	https://doi.org/10.1101/gad.9.23.2888
State	Published - Dec 1 1995

Keywords

HST genes
Saccharomyces cerevisiae
chromosome segregation
homologous recombination
telomeric silencing

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.9.23.2888

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abstract = "Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals. At least three HST genes can function in silencing; HST1 overexpression restores transcriptional silencing to a sir2 mutant and hst3 hst4 double mutants are defective in telomeric silencing. In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes.",

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T1 - The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

AU - Brachmann, Carrie Baker

AU - Sherman, Joyce M.

AU - Devine, Scott E.

AU - Cameron, Elizabeth E.

AU - Pillus, Lorraine

AU - Boeke, Jef D.

PY - 1995/12/1

Y1 - 1995/12/1

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AB - Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals. At least three HST genes can function in silencing; HST1 overexpression restores transcriptional silencing to a sir2 mutant and hst3 hst4 double mutants are defective in telomeric silencing. In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes.

KW - HST genes

KW - Saccharomyces cerevisiae

KW - chromosome segregation

KW - homologous recombination

KW - telomeric silencing

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The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

Abstract

Keywords

ASJC Scopus subject areas

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