The State of Systems Genetics in 2017

Nitin S. Baliga; Johan L.M. Björkegren; Jef D. Boeke; Michael Boutros; Nigel P.S. Crawford; Aimée M. Dudley; Charles R. Farber; Allan Jones; Allan I. Levey; Aldons J. Lusis; H. Craig Mak; Joseph H. Nadeau; Marcus B. Noyes; Enrico Petretto; Nicholas T. Seyfried; Lars M. Steinmetz; Sibylle C. Vonesch

doi:10.1016/j.cels.2017.01.005

The State of Systems Genetics in 2017

Nitin S. Baliga, Johan L.M. Björkegren, Jef D. Boeke, Michael Boutros, Nigel P.S. Crawford, Aimée M. Dudley, Charles R. Farber, Allan Jones, Allan I. Levey, Aldons J. Lusis, H. Craig Mak, Joseph H. Nadeau, Marcus B. Noyes, Enrico Petretto, Nicholas T. Seyfried, Lars M. Steinmetz, Sibylle C. Vonesch

Biomedical Engineering

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Cell Systems invited 16 experts to share their views on the field of systems genetics. In questions repeated in the headings, we asked them to define systems genetics, highlight its relevance to researchers outside the field, discuss what makes a strong systems genetics paper, and paint a picture of where the field is heading in the coming years. Their responses, ordered by the journal but otherwise unedited, make it clear that deciphering genotype to phenotype relationships is a central challenge of systems genetics and will require understanding how networks and higher-order properties of biological systems underlie complex traits. In addition, our experts illuminate the applications and relevance of systems genetics to human disease, the gut microbiome, development of tools that connect the global research community, sustainability, drug discovery, patient-specific disease and network models, and personalized treatments. Finally, a table of suggested reading provides a sample of influential work in the field.

Original language	English (US)
Pages (from-to)	7-15
Number of pages	9
Journal	Cell Systems
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/j.cels.2017.01.005
State	Published - Jan 25 2017

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Cell Biology

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Baliga, N. S., Björkegren, J. L. M., Boeke, J. D., Boutros, M., Crawford, N. P. S., Dudley, A. M., Farber, C. R., Jones, A., Levey, A. I., Lusis, A. J., Mak, H. C., Nadeau, J. H., Noyes, M. B., Petretto, E., Seyfried, N. T., Steinmetz, L. M., & Vonesch, S. C. (2017). The State of Systems Genetics in 2017. Cell Systems, 4(1), 7-15. https://doi.org/10.1016/j.cels.2017.01.005

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abstract = "Cell Systems invited 16 experts to share their views on the field of systems genetics. In questions repeated in the headings, we asked them to define systems genetics, highlight its relevance to researchers outside the field, discuss what makes a strong systems genetics paper, and paint a picture of where the field is heading in the coming years. Their responses, ordered by the journal but otherwise unedited, make it clear that deciphering genotype to phenotype relationships is a central challenge of systems genetics and will require understanding how networks and higher-order properties of biological systems underlie complex traits. In addition, our experts illuminate the applications and relevance of systems genetics to human disease, the gut microbiome, development of tools that connect the global research community, sustainability, drug discovery, patient-specific disease and network models, and personalized treatments. Finally, a table of suggested reading provides a sample of influential work in the field.",

author = "Baliga, {Nitin S.} and Bj{\"o}rkegren, {Johan L.M.} and Boeke, {Jef D.} and Michael Boutros and Crawford, {Nigel P.S.} and Dudley, {Aim{\'e}e M.} and Farber, {Charles R.} and Allan Jones and Levey, {Allan I.} and Lusis, {Aldons J.} and Mak, {H. Craig} and Nadeau, {Joseph H.} and Noyes, {Marcus B.} and Enrico Petretto and Seyfried, {Nicholas T.} and Steinmetz, {Lars M.} and Vonesch, {Sibylle C.}",

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AU - Crawford, Nigel P.S.

AU - Dudley, Aimée M.

AU - Farber, Charles R.

AU - Jones, Allan

AU - Levey, Allan I.

AU - Lusis, Aldons J.

AU - Mak, H. Craig

AU - Nadeau, Joseph H.

AU - Noyes, Marcus B.

AU - Petretto, Enrico

AU - Seyfried, Nicholas T.

AU - Steinmetz, Lars M.

AU - Vonesch, Sibylle C.

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The State of Systems Genetics in 2017

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ASJC Scopus subject areas

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