The T Cell Journey: A Tour de Force

Aseel Alatoom, Mei ElGindi, Jiranuwat Sapudom, Jeremy C.M. Teo

Research output: Contribution to journalReview articlepeer-review


T cells act as the puppeteers in the adaptive immune response, and their dysfunction leads to the initiation and progression of pathological conditions. During their lifetime, T cells experience myriad forces that modulate their effector functions. These forces are imposed by interacting cells, surrounding tissues, and shear forces from fluid movement. In this review, a journey with T cells is made, from their development to their unique characteristics, including the early studies that uncovered their mechanosensitivity. Then the studies pertaining to the responses of T cell activation to changes in antigen-presenting cells’ physical properties, to their immediate surrounding extracellular matrix microenvironment, and flow conditions are highlighted. In addition, it is explored how pathological conditions like the tumor microenvironment can hinder T cells and allow cancer cells to escape elimination.

Original languageEnglish (US)
Article number2200173
JournalAdvanced Biology
Issue number1
StatePublished - Jan 2023


  • T cells
  • adaptive immunity
  • biomechanics
  • immunomechanobiology
  • mechanobiology

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • General Biochemistry, Genetics and Molecular Biology


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