The tactile sensors of the gut

Sarah A. Najjar, Kara Gross Margolis

Research output: Contribution to journalShort surveypeer-review


In a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.

Original languageEnglish (US)
Pages (from-to)173-175
Number of pages3
JournalTrends in Neurosciences
Issue number3
StatePublished - Mar 2022


  • GI physiology
  • Piezo2
  • enteroendocrine cells
  • ion channels
  • mechanosensitivity
  • neuroepithelial connection

ASJC Scopus subject areas

  • General Neuroscience


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