TY - JOUR
T1 - The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration
AU - Peixoto, Pablo M.
AU - Dejean, Laurent M.
AU - Kinnally, Kathleen W.
N1 - Funding Information:
This work was supported by NIH grant GM57249 to Kathleen W. Kinnally.
PY - 2012/1
Y1 - 2012/1
N2 - Mitochondria communicate with the rest of the cell through channels located in their inner and outer membranes. Most of the time, the message is encoded by the flow of anions and cations e.g., through VDAC and PTP, respectively. However, proteins are also both imported and exported across the mitochondrial membranes e.g., through TOM and MAC, respectively. Transport through mitochondrial channels is exquisitely regulated and controls a myriad of processes; from energy production to cell death. Here, we examine the role of some of the mitochondrial channels involved in neurodegeneration, ischemia-reperfusion injury and cancer in the context of their potential as therapeutic targets.
AB - Mitochondria communicate with the rest of the cell through channels located in their inner and outer membranes. Most of the time, the message is encoded by the flow of anions and cations e.g., through VDAC and PTP, respectively. However, proteins are also both imported and exported across the mitochondrial membranes e.g., through TOM and MAC, respectively. Transport through mitochondrial channels is exquisitely regulated and controls a myriad of processes; from energy production to cell death. Here, we examine the role of some of the mitochondrial channels involved in neurodegeneration, ischemia-reperfusion injury and cancer in the context of their potential as therapeutic targets.
KW - Cancer
KW - Degenerative diseases
KW - MAC (mitochondrial apoptosis-induced channel)
KW - Mitochondrial channels
KW - PTP (permeability transition pore)
KW - VDAC (voltage dependent anion channel)
UR - http://www.scopus.com/inward/record.url?scp=84856541576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856541576&partnerID=8YFLogxK
U2 - 10.1016/j.mito.2011.03.003
DO - 10.1016/j.mito.2011.03.003
M3 - Review article
C2 - 21406252
AN - SCOPUS:84856541576
SN - 1567-7249
VL - 12
SP - 14
EP - 23
JO - Mitochondrion
JF - Mitochondrion
IS - 1
ER -