The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration

Pablo M. Peixoto, Laurent M. Dejean, Kathleen W. Kinnally

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitochondria communicate with the rest of the cell through channels located in their inner and outer membranes. Most of the time, the message is encoded by the flow of anions and cations e.g., through VDAC and PTP, respectively. However, proteins are also both imported and exported across the mitochondrial membranes e.g., through TOM and MAC, respectively. Transport through mitochondrial channels is exquisitely regulated and controls a myriad of processes; from energy production to cell death. Here, we examine the role of some of the mitochondrial channels involved in neurodegeneration, ischemia-reperfusion injury and cancer in the context of their potential as therapeutic targets.

Original languageEnglish (US)
Pages (from-to)14-23
Number of pages10
JournalMitochondrion
Volume12
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Cancer
  • Degenerative diseases
  • MAC (mitochondrial apoptosis-induced channel)
  • Mitochondrial channels
  • PTP (permeability transition pore)
  • VDAC (voltage dependent anion channel)

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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