The time of tumor cell division and death depends on the site of growth

Lucas Luis Colombo, Esteban O. Mazzoni, Roberto Pablo Meiss

Research output: Contribution to journalArticlepeer-review


We show here, for the first time, in two very different murine tumors, a mammary one (ectoderm) and a lung one (endoderm), that: tumors have day/night differences of spontaneous apoptosis additional to the well-known circadian rhythm of mitosis. The times of maximal and minimal mitosis and apoptosis changed for a tumor cell line when growing in different organs (as metastasis) or anatomical sites. Both tumor lines, have identical circadian curves when growing in a specific organ or anatomical site. The peaks of apoptosis match with the valleys of mitosis and vice versa.

Original languageEnglish (US)
Pages (from-to)1363-1366
Number of pages4
JournalOncology Reports
Issue number6
StatePublished - 2000


  • Apoptosis
  • Cell death
  • Circadian rhythm
  • Metastasis
  • Mitosis
  • Organ microenvironment
  • Tumor growth

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'The time of tumor cell division and death depends on the site of growth'. Together they form a unique fingerprint.

Cite this