The ups and downs of repetition: Modulation of the perirhinal cortex by conceptual repetition predicts priming and long-term memory

Andrew C. Heusser, Tarimotimi Awipi, Lila Davachi

Research output: Contribution to journalArticlepeer-review

Abstract

In order to better understand how concepts might be represented in the brain, we used a cross-modal conceptual priming paradigm to examine how repetition-related activity changes in the brain are related to conceptual priming. During scanning, subjects made natural/manmade judgments on a continuous stream of spoken nouns, written nouns and pictures of objects. Each stimulus either repeated in the same or a different modality with 1-4 intervening trials between repetitions. Behaviorally, participants showed significant perceptual and conceptual priming effects. The fMRI data showed that the conditions associated with the greatest behavioral priming exhibited the largest decreases in BOLD activity in left perirhinal cortex (PRc), as well as a few other regions. Furthermore, the PRc was the only region to show this relationship for the cross-modal conditions alone, where the concept but not the percept repeated. Conversely, repetition-related increases in PRc activity predicted better subsequent memory as assessed by a post-scan recognition test. These results suggest that repetition-related activity changes in the PRc are related both to the speed of access to a repeated concept and to that concept's later memorability.

Original languageEnglish (US)
Pages (from-to)2333-2343
Number of pages11
JournalNeuropsychologia
Volume51
Issue number12
DOIs
StatePublished - Oct 2013

Keywords

  • Conceptual priming
  • Cross-modal
  • Long-term memory
  • Perirhinal cortex
  • Repetition enhancement
  • Repetition suppression

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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