The wending rhombus: Self-assembling 3D DNA crystals

Brandon Lu, Simon Vecchioni, Yoel P. Ohayon, James W. Canary, Ruojie Sha

Research output: Contribution to journalReview articlepeer-review


In this perspective, we provide a summary of recent developments in self-assembling three-dimensional (3D) DNA crystals. Starting from the inception of this subfield, we describe the various advancements in structure that have led to an increase in the diversity of macromolecular crystal motifs formed through self-assembly, and we further comment on the future directions of the field, which exploit noncanonical base pairing interactions beyond Watson-Crick. We then survey the current applications of self-assembling 3D DNA crystals in reversibly active nanodevices and materials engineering and provide an outlook on the direction researchers are taking these structures. Finally, we compare 3D DNA crystals with DNA origami and suggest how these distinct subfields might work together to enhance biomolecule structure solution, nanotechnological motifs, and their applications.

Original languageEnglish (US)
Pages (from-to)4759-4765
Number of pages7
JournalBiophysical journal
Issue number24
StatePublished - Dec 20 2022

ASJC Scopus subject areas

  • Biophysics


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