@inproceedings{15124bd289ee4ea988c9f28489d2b995,
title = "The whispering gallery mode biosensor: Label-free detection from virus to single protein",
abstract = "The whispering gallery mode (WGM) biosensor is a micro-optical platform capable of sensitive label-free detection of biological particles. Described by the reactive sensing principle (RSP), this analytic formulation quantifies the response of the system to the adsorption of bioparticles. Guided by the RSP, the WGM biosensor enabling from detection of virus (e.g., Human Papillomavirus, HPV) to the ultimate goal of single protein detection. The latter was derived from insights into the RSP, which resulted in the development of a hybrid plasmonic WGM biosensor, which has recently demonstrated detection of individual protein cancer markers. Enhancements from bound gold nanoparticles provide the sensitivity to detect single protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa.",
keywords = "Whispering gallery mode, biosensing, microcavity, photonics, plasmonics, reactive sensing principle, resonance, single protein",
author = "S. Holler and Dantham, {V. R.} and D. Keng and V. Kolchenko and S. Arnold and Brigid Mulroe and M. Paspaley-Grbavac",
note = "Publisher Copyright: {\textcopyright} 2014 SPIE.; Biosensing and Nanomedicine VII ; Conference date: 17-08-2014",
year = "2014",
doi = "10.1117/12.2061477",
language = "English (US)",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Agahi, {Massoud H.} and Hooman Mohseni and Manijeh Razeghi",
booktitle = "Biosensing and Nanomedicine VII",
}