TY - GEN
T1 - Theoretical and experimental studies of the mammalian respiratory rhythm generator
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
AU - Butera, Robert J.
AU - DelNegro, Christopher
AU - Rinzel, John
AU - Smith, Jeffrey C.
PY - 1999
Y1 - 1999
N2 - The pacemaking kernel generating the respiratory rhythm in mammals is hypothesized to be a subnetwork of pacemaker neurons with intrinsic voltage-dependent bursting properties in the pre-Botzinger complex (pre-BotC). An in vitro transverse slice preparation has been developed that captures this kernel and continues to be rhythmically active, allowing respiratory rhythm generation to be studied at the cellular level. We have used complementary experimental and computational modeling approaches to investigate the cellular and synaptic components underlying rhythm generation in the pre-BotC of slices. These approaches have supported the pacemaker-network hypothesis for the rhythm generator and provide the basis for development of a more complete model of the mammalian respiratory control system.
AB - The pacemaking kernel generating the respiratory rhythm in mammals is hypothesized to be a subnetwork of pacemaker neurons with intrinsic voltage-dependent bursting properties in the pre-Botzinger complex (pre-BotC). An in vitro transverse slice preparation has been developed that captures this kernel and continues to be rhythmically active, allowing respiratory rhythm generation to be studied at the cellular level. We have used complementary experimental and computational modeling approaches to investigate the cellular and synaptic components underlying rhythm generation in the pre-BotC of slices. These approaches have supported the pacemaker-network hypothesis for the rhythm generator and provide the basis for development of a more complete model of the mammalian respiratory control system.
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M3 - Conference contribution
AN - SCOPUS:0033350480
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 1175
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
Y2 - 13 October 1999 through 16 October 1999
ER -