Theories of blood coagulation

James P. Riddel, Bradley E. Aouizerat, Christine Miaskowski, David P. Lillicrap

Research output: Contribution to journalReview articlepeer-review


Although the concept of the coagulation cascade represented a significant advance in the understanding of coagulation and served for many years as a useful model, more recent clinical and experimental observations demonstrate that the cascade/waterfall hypothesis does not fully and completely reflect the events of hemostasis in vivo. The goal of this article is to review the evolution of the theories of coagulation and their proposed models to serve as a tool when reviewing the research and practice literature that was published in the context of these different theories over time.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalJournal of Pediatric Oncology Nursing
Issue number3
StatePublished - May 2007


  • Bleeding disorders
  • Cell-based theory of coagulation
  • Coagulation
  • Coagulation cascade

ASJC Scopus subject areas

  • Pediatrics
  • Oncology(nursing)


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