Therapeutic synthetic and natural materials for immunoengineering

Anna Slezak, Kevin Chang, Samir Hossainy, Aslan Mansurov, Stuart J. Rowan, Jeffrey A. Hubbell, Mustafa O. Guler

Research output: Contribution to journalReview articlepeer-review

Abstract

Immunoengineering is a rapidly evolving field that has been driving innovations in manipulating immune system for new treatment tools and methods. The need for materials for immunoengineering applications has gained significant attention in recent years due to the growing demand for effective therapies that can target and regulate the immune system. Biologics and biomaterials are emerging as promising tools for controlling immune responses, and a wide variety of materials, including proteins, polymers, nanoparticles, and hydrogels, are being developed for this purpose. In this review article, we explore the different types of materials used in immunoengineering applications, their properties and design principles, and highlight the latest therapeutic materials advancements. Recent works in adjuvants, vaccines, immune tolerance, immunotherapy, and tissue models for immunoengineering studies are discussed.

Original languageEnglish (US)
Pages (from-to)1789-1822
Number of pages34
JournalChemical Society Reviews
Volume53
Issue number4
DOIs
StatePublished - Jan 3 2024

ASJC Scopus subject areas

  • General Chemistry

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