Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule

Vijay S. Pande; Alexander Y. Grosberg; Toyoichi Tanaka

doi:10.1073/pnas.91.26.12976

Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule

Vijay S. Pande, Alexander Y. Grosberg, Toyoichi Tanaka

Research output: Contribution to journal › Article › peer-review

Abstract

We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an 'active site' capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.

Original language	English (US)
Pages (from-to)	12976-12979
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	91
Issue number	26
DOIs	https://doi.org/10.1073/pnas.91.26.12976
State	Published - Dec 20 1994

Keywords

molecular recognition
renaturation

ASJC Scopus subject areas

General

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10.1073/pnas.91.26.12976

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abstract = "We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an 'active site' capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.",

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AU - Grosberg, Alexander Y.

AU - Tanaka, Toyoichi

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KW - renaturation

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Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule

Abstract

Keywords

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