We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an 'active site' capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Dec 20 1994|
- molecular recognition
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