Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule

Vijay S. Pande, Alexander Y. Grosberg, Toyoichi Tanaka

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an 'active site' capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.

    Original languageEnglish (US)
    Pages (from-to)12976-12979
    Number of pages4
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume91
    Issue number26
    DOIs
    StatePublished - Dec 20 1994

    Keywords

    • molecular recognition
    • renaturation

    ASJC Scopus subject areas

    • General

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