Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells

Shutao Wang; Hao Wang; Jing Jiao; Kuan Ju Chen; Gwen E. Owens; Ken Ichiro Kamei; Jing Sun; David J. Sherman; Christian P. Behrenbruch; Hong Wu; Hsian Rong Tseng

doi:10.1002/anie.200901668

Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells

Shutao Wang, Hao Wang, Jing Jiao, Kuan Ju Chen, Gwen E. Owens, Ken Ichiro Kamei, Jing Sun, David J. Sherman, Christian P. Behrenbruch, Hong Wu, Hsian Rong Tseng

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

A grabby substrate: A 3D nanostructured substrate, namely, a silicon-nanopillar (SiNP) array coated with epithelial-cell adhesion-molecule antibody (antiEpCAM), shows enhanced local topographic interactions between nanoscale cell-surface components and the substrates surface, resulting in enhanced cellcapture efficiency when employed to isolate viable cancer cells from whole-blood samples (see schematic and SEM image of a captured cancer cell).

Original language	English (US)
Pages (from-to)	8970-8973
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	47
DOIs	https://doi.org/10.1002/anie.200901668
State	Published - Nov 9 2009

Keywords

Cancer diagnosis
Cell capture
Nanostructures
Silicon

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200901668

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abstract = "A grabby substrate: A 3D nanostructured substrate, namely, a silicon-nanopillar (SiNP) array coated with epithelial-cell adhesion-molecule antibody (antiEpCAM), shows enhanced local topographic interactions between nanoscale cell-surface components and the substrates surface, resulting in enhanced cellcapture efficiency when employed to isolate viable cancer cells from whole-blood samples (see schematic and SEM image of a captured cancer cell).",

keywords = "Cancer diagnosis, Cell capture, Nanostructures, Silicon",

author = "Shutao Wang and Hao Wang and Jing Jiao and Chen, {Kuan Ju} and Owens, {Gwen E.} and Kamei, {Ken Ichiro} and Jing Sun and Sherman, {David J.} and Behrenbruch, {Christian P.} and Hong Wu and Tseng, {Hsian Rong}",

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doi = "10.1002/anie.200901668",

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AU - Wang, Shutao

AU - Wang, Hao

AU - Jiao, Jing

AU - Chen, Kuan Ju

AU - Owens, Gwen E.

AU - Kamei, Ken Ichiro

AU - Sun, Jing

AU - Sherman, David J.

AU - Behrenbruch, Christian P.

AU - Wu, Hong

AU - Tseng, Hsian Rong

PY - 2009/11/9

Y1 - 2009/11/9

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AB - A grabby substrate: A 3D nanostructured substrate, namely, a silicon-nanopillar (SiNP) array coated with epithelial-cell adhesion-molecule antibody (antiEpCAM), shows enhanced local topographic interactions between nanoscale cell-surface components and the substrates surface, resulting in enhanced cellcapture efficiency when employed to isolate viable cancer cells from whole-blood samples (see schematic and SEM image of a captured cancer cell).

KW - Cancer diagnosis

KW - Cell capture

KW - Nanostructures

KW - Silicon

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells

Abstract

Keywords

ASJC Scopus subject areas

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