Three-dimensional optical tomographic imaging of vascular reactivity in the brain

Andreas H. Hielscher, Avraham Y. Bluestone, Gassan S. Abdoulaev, Joseph Lasker, Randall L. Barbour, Christoph H. Schmitz

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We report on the first three-dimensional, volumetric, tomographic localization of changes in the concentration of oxyhemoglobin and deoxyhemoglobin in the brain. To this end we have developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin and deoxyhemoglobin during a Valsalva maneuver are visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

    Original languageEnglish (US)
    Pages (from-to)207-218
    Number of pages12
    JournalProceedings of SPIE-The International Society for Optical Engineering
    Volume4431
    DOIs
    StatePublished - 2001

    Keywords

    • Blood/tissue constituent monitoring
    • Brain imaging
    • Optical tomography
    • Volumetric imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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