Three-dimensional optical tomographic imaging of vascular reactivity in the brain

Andreas H. Hielscher; Avraham Y. Bluestone; Gassan S. Abdoulaev; Joseph Lasker; Randall L. Barbour; Christoph H. Schmitz

doi:10.1117/12.447424

Three-dimensional optical tomographic imaging of vascular reactivity in the brain

Andreas H. Hielscher, Avraham Y. Bluestone, Gassan S. Abdoulaev, Joseph Lasker, Randall L. Barbour, Christoph H. Schmitz

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We report on the first three-dimensional, volumetric, tomographic localization of changes in the concentration of oxyhemoglobin and deoxyhemoglobin in the brain. To this end we have developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin and deoxyhemoglobin during a Valsalva maneuver are visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

Original language	English (US)
Pages (from-to)	207-218
Number of pages	12
Journal	Proceedings of SPIE-The International Society for Optical Engineering
Volume	4431
DOIs	https://doi.org/10.1117/12.447424
State	Published - 2001

Keywords

Blood/tissue constituent monitoring
Brain imaging
Optical tomography
Volumetric imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.447424

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abstract = "We report on the first three-dimensional, volumetric, tomographic localization of changes in the concentration of oxyhemoglobin and deoxyhemoglobin in the brain. To this end we have developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin and deoxyhemoglobin during a Valsalva maneuver are visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.",

keywords = "Blood/tissue constituent monitoring, Brain imaging, Optical tomography, Volumetric imaging",

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AU - Hielscher, Andreas H.

AU - Bluestone, Avraham Y.

AU - Abdoulaev, Gassan S.

AU - Lasker, Joseph

AU - Barbour, Randall L.

AU - Schmitz, Christoph H.

PY - 2001

Y1 - 2001

N2 - We report on the first three-dimensional, volumetric, tomographic localization of changes in the concentration of oxyhemoglobin and deoxyhemoglobin in the brain. To this end we have developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin and deoxyhemoglobin during a Valsalva maneuver are visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

AB - We report on the first three-dimensional, volumetric, tomographic localization of changes in the concentration of oxyhemoglobin and deoxyhemoglobin in the brain. To this end we have developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin and deoxyhemoglobin during a Valsalva maneuver are visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

KW - Blood/tissue constituent monitoring

KW - Brain imaging

KW - Optical tomography

KW - Volumetric imaging

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JF - Proceedings of SPIE-The International Society for Optical Engineering

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Three-dimensional optical tomographic imaging of vascular reactivity in the brain

Abstract

Keywords

ASJC Scopus subject areas

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