Three-dimensional optical-tomographic localization of changes in absorption coefficients in the human brain

A. Bluestone; G. Abdoulaev; R. Barbour; C. Schmitz; A. H. Hielscher

doi:10.1117/12.434496

Three-dimensional optical-tomographic localization of changes in absorption coefficients in the human brain

A. Bluestone, G. Abdoulaev, R. Barbour, C. Schmitz, A. H. Hielscher

Research output: Contribution to journal › Conference article › peer-review

Abstract

We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show the spatial distribution of changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, three-dimensional, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying tissues.

Original language	English (US)
Pages (from-to)	258-268
Number of pages	11
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4250
DOIs	https://doi.org/10.1117/12.434496
State	Published - 2001
Event	Optical Tomography and Spectroscopy of Tissue IV - San Jose, CA, United States Duration: Jan 21 2001 → Jan 23 2001

Keywords

Brain imaging
Diffuse optical tomography
Reverse-problem
Three-dimensional imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.434496

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title = "Three-dimensional optical-tomographic localization of changes in absorption coefficients in the human brain",

abstract = "We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show the spatial distribution of changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, three-dimensional, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying tissues.",

keywords = "Brain imaging, Diffuse optical tomography, Reverse-problem, Three-dimensional imaging",

author = "A. Bluestone and G. Abdoulaev and R. Barbour and C. Schmitz and Hielscher, {A. H.}",

year = "2001",

doi = "10.1117/12.434496",

language = "English (US)",

volume = "4250",

pages = "258--268",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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note = "Optical Tomography and Spectroscopy of Tissue IV ; Conference date: 21-01-2001 Through 23-01-2001",

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TY - JOUR

T1 - Three-dimensional optical-tomographic localization of changes in absorption coefficients in the human brain

AU - Bluestone, A.

AU - Abdoulaev, G.

AU - Barbour, R.

AU - Schmitz, C.

AU - Hielscher, A. H.

PY - 2001

Y1 - 2001

N2 - We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show the spatial distribution of changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, three-dimensional, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying tissues.

AB - We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show the spatial distribution of changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, three-dimensional, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying tissues.

KW - Brain imaging

KW - Diffuse optical tomography

KW - Reverse-problem

KW - Three-dimensional imaging

UR - http://www.scopus.com/inward/record.url?scp=0034872222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034872222&partnerID=8YFLogxK

U2 - 10.1117/12.434496

DO - 10.1117/12.434496

M3 - Conference article

AN - SCOPUS:0034872222

VL - 4250

SP - 258

EP - 268

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

SN - 0277-786X

T2 - Optical Tomography and Spectroscopy of Tissue IV

Y2 - 21 January 2001 through 23 January 2001

ER -

Three-dimensional optical-tomographic localization of changes in absorption coefficients in the human brain

Abstract

Keywords

ASJC Scopus subject areas

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