Three-dimensional optical-tomographic localization of changes in absorption coefficients in the human brain

A. Bluestone, G. Abdoulaev, R. Barbour, C. Schmitz, A. H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show the spatial distribution of changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, three-dimensional, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying tissues.

Original languageEnglish (US)
Title of host publicationOptical Tomography and Spectroscopy of Tissue IV
Subtitle of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages258-268
Number of pages11
Volume4250
DOIs
StatePublished - 2001
EventOptical Tomography and Spectroscopy of Tissue IV - San Jose, CA, United States
Duration: Jan 21 2001Jan 23 2001

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
PublisherSPIE
ISSN (Print)0277-786X

Conference

ConferenceOptical Tomography and Spectroscopy of Tissue IV
Country/TerritoryUnited States
CitySan Jose, CA
Period1/21/011/23/01

Keywords

  • Brain imaging
  • Diffuse optical tomography
  • Reverse-problem
  • Three-dimensional imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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