Three-dimensional optical-tomographic localization of changes in absorption coefficients in the human brain

A. Bluestone, G. Abdoulaev, R. Barbour, C. Schmitz, A. H. Hielscher

    Research output: Contribution to journalConference articlepeer-review

    Abstract

    We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show the spatial distribution of changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, three-dimensional, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying tissues.

    Original languageEnglish (US)
    Pages (from-to)258-268
    Number of pages11
    JournalProceedings of SPIE - The International Society for Optical Engineering
    Volume4250
    DOIs
    StatePublished - 2001
    EventOptical Tomography and Spectroscopy of Tissue IV - San Jose, CA, United States
    Duration: Jan 21 2001Jan 23 2001

    Keywords

    • Brain imaging
    • Diffuse optical tomography
    • Reverse-problem
    • Three-dimensional imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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