Three-dimensional optical tomography of hemodynamics in the human head

Avraham Y. Bluestone, Gassan Abdoulaev, Christoph H. Schmitz, Randall L. Barbour, Andreas H. Hielscher

Research output: Contribution to journalArticlepeer-review


We report on the first three-dimensional, volumetric, tomographic localization of vascular reactivity in the brain, To this end we developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. The necessary human-head geometry and optode locations were determined with a photogrammetric method. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin during a Valsalva maneuver were visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

Original languageEnglish (US)
Pages (from-to)272-286
Number of pages15
JournalOptics Express
Issue number6
StatePublished - Sep 2001

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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