Three-dimensional retinal imaging with ultrahigh resolution, Fourier/spectral domain optical coherence tomography

Vivek Srinivasan, Maciej Wojtkowski, Tony Ko, Mariana Carvalho, James Fujimoto, Jay Duker, Joel Schumann, Andrzej Kowalczyk

Research output: Contribution to journalConference articlepeer-review


Ultrahigh resolution OCT using broadband light sources achieves improved axial image resolutions of ∼ 2-3 urn compared to standard 10 um resolution OCT used in current commercial instruments. High-speed OCT using Fourier/spectral domain detection enables dramatic increases in imaging speeds. 3D OCT retinal imaging is performed in human subjects using high-speed, ultrahigh resolution OCT, and the concept of an OCT fundus image is introduced. Three-dimensional data and high quality cross-sectional images of retinal pathologies are presented. These results show that 3D OCT may be used to improve coverage of the retina, precision of cross-sectional image registration, quality of cross-sectional images, and visualization of subtle changes in retinal topography. 3D OCT imaging and mapping promise to help elucidate the structural changes associated with retinal disease as well as to improve early diagnosis and monitoring of disease progression and response to treatment.

Original languageEnglish (US)
Article number19
Pages (from-to)90-99
Number of pages10
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2005
EventOphtalmic Technologies XV - San Jose, CA, United States
Duration: Jan 22 2005Jan 25 2005


  • 3D
  • Mapping
  • Ophthalmology
  • Optical Coherence Tomography
  • Rendering
  • Segmentation
  • StratusOCT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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