Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration

Yueli Chen, Laurel N. Vuong, Jonathan Liu, Joseph Ho, Vivek J. Srinivasan, Iwona Gorczynska, Andre J. Witkin, Jay S. Duker, Joel Schuman, James G. Fujimoto

Research output: Contribution to journalArticlepeer-review


Ultrahigh resolution optical coherence tomography (OCT) enhances the ability to visualize different intra retinal layers. In age-related macular degeneration (AMD), pathological changes in individual retinal layers, including photoreceptor inner and outer segments and retinal pigment epithelium, can be detected. OCT using spectral / Fourier domain detection enables high speed, volumetric imaging of the macula, which provides comprehensive three-dimensional tomographic and morphologic information. We present a case series of AMD patients, from mild drusen to more advanced geographic atrophy and exudative AMD. Patients were imaged with a research prototype, ultrahigh resolution spectral / Fourier domain OCT instrument with 3.5 μm axial image resolution operating at 25,000 axial scans per second. These cases provide representative volumetric dataseis of well-documented AMD pathologies which could be used for the development of visualization and imaging processing methods and algorithms.

Original languageEnglish (US)
Pages (from-to)4046-4060
Number of pages15
JournalOptics Express
Issue number5
StatePublished - Mar 2 2009

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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