TY - JOUR
T1 - Through the Microbial Looking Glass
T2 - Premature Labor, Preeclampsia, and Gestational Diabetes: A Scoping Review
AU - Dunn, Alexis B.
AU - Hanson, Lisa
AU - Vandevusse, Leona
AU - Leslie, Sharon
N1 - Funding Information:
Authors Hanson and VanderVusse are currently funded on a project from the National Institute of Child Health and Human Development of the National Institutes of Health (1R21HD095320-01). The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The influence of microbial factors on adverse perinatal outcomes has become the focal point of recent investigations, with particular interest in the role of the microbiome and probiotic interventions. The purpose of this scoping review was to identify and critique the most recent evidence about these factors as they relate to pregnancies complicated by preeclampsia (PEC), preterm birth (PTB), and gestational diabetes mellitus (GDM). Four databases (PubMed, EMBASE, Web of Science, and Cochrane) were searched for articles published in English in the last 10 years with the concepts of the microbiome, probiotics, and PEC, PTB, or GDM. Forty-nine articles were eligible for full-text review. Five articles were excluded, leaving 44 articles that met all the eligibility criteria. The relationships between the microbiome and the risk for PEC, PTB, and GDM are not fully elucidated, although probiotic interventions seem beneficial in decreasing PEC and GDM risk. Probiotic interventions targeting bacterial vaginosis and elimination of infection in women at risk for PTB appear to be beneficial. More research is needed to understand the contributions of the microbiome to adverse perinatal outcomes. Probiotic interventions appear to be effective in reducing risk for select outcomes.
AB - The influence of microbial factors on adverse perinatal outcomes has become the focal point of recent investigations, with particular interest in the role of the microbiome and probiotic interventions. The purpose of this scoping review was to identify and critique the most recent evidence about these factors as they relate to pregnancies complicated by preeclampsia (PEC), preterm birth (PTB), and gestational diabetes mellitus (GDM). Four databases (PubMed, EMBASE, Web of Science, and Cochrane) were searched for articles published in English in the last 10 years with the concepts of the microbiome, probiotics, and PEC, PTB, or GDM. Forty-nine articles were eligible for full-text review. Five articles were excluded, leaving 44 articles that met all the eligibility criteria. The relationships between the microbiome and the risk for PEC, PTB, and GDM are not fully elucidated, although probiotic interventions seem beneficial in decreasing PEC and GDM risk. Probiotic interventions targeting bacterial vaginosis and elimination of infection in women at risk for PTB appear to be beneficial. More research is needed to understand the contributions of the microbiome to adverse perinatal outcomes. Probiotic interventions appear to be effective in reducing risk for select outcomes.
KW - gestational diabetes
KW - microbiome
KW - prebiotics
KW - preeclampsia
KW - preterm birth
KW - probiotics
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U2 - 10.1097/JPN.0000000000000375
DO - 10.1097/JPN.0000000000000375
M3 - Article
C2 - 30676461
AN - SCOPUS:85060373272
SN - 0893-2190
VL - 33
SP - 35
EP - 51
JO - Journal of Perinatal and Neonatal Nursing
JF - Journal of Perinatal and Neonatal Nursing
IS - 1
ER -