Time-dependent diffusion in prostate cancer

Gregory Lemberskiy, Andrew B. Rosenkrantz, Jelle Veraart, Samir S. Taneja, Dmitry S. Novikov, Els Fieremans

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: Prior studies in prostate diffusion-weightedmagnetic resonance imaging (MRI) have largely explored the impact of b-value and diffusion directions on estimated diffusion coefficient D. Here we suggest varying diffusion time, t, to study time-dependent D(t) in prostate cancer, thereby adding an extra dimension in the development of prostate cancer biomarkers. Methods: Thirty-eight patients with peripheral zone prostate cancer underwent 3-T MRI using an external-array coil and a diffusion-weighted image sequence acquired for b = 0, as well as along 12 noncollinear gradient directions for b = 500 s/mm2 using stimulated echo acquisition mode (STEAM) diffusion tensor imaging (DTI). For this sequence, 6 diffusion times ranging from 20.8 to 350 milliseconds were acquired. Tumors were classified as low-grade (Gleason score [GS] 3 + 3; n = 11), intermediate-grade (GS 3 + 4; n = 16), and highgrade (GS ≥4 + 3; n = 11). Benign peripheral zone and transition zone were also studied. Results: Apparent diffusion coefficient (ADC) D(t) decreased with increasing t in all zones of the prostate, though the rate of decay in D(t) was different between sampled zones. Analysis of variance and area under the curve analyses suggested better differentiation of tumor grades at shorter t. Fractional anisotropy (FA) increased with t for all regions of interest. On average, highest FA was observed within GS 3 + 3 tumors. Conclusions: There is a measurable time dependence of ADC in prostate cancer, which is dependent on the underlying tissue and Gleason score. Therefore, there may be an optimal selection of t for prediction of tumor grade using ADC. Controlling t should allow ADC to achieve greater reproducibility between different sites and vendors. Intentionally varying t enables targeted exploration of D(t), a previously overlooked biophysical phenomenon in the prostate. Its further microstructural understanding and modeling may lead to novel diffusion-derived biomarkers.

    Original languageEnglish (US)
    Pages (from-to)405-411
    Number of pages7
    JournalInvestigative Radiology
    Volume52
    Issue number7
    DOIs
    StatePublished - 2017

    Keywords

    • Fractional anisotropy prostate cancer
    • Prostate cancer diffusion
    • Time-dependent diffusion

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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