Time-dependent modulation of serotonin and its receptors 1A and 2A expression in allergic contact dermatitis

J. Wetterberg, C. Taher, E. C. Azmitia, H. El-Nour

Research output: Contribution to journalArticlepeer-review

Abstract

Background Serotonin implication in allergic contact dermatitis was earlier suggested. Objective To study the expression of serotonin (5-HT) and its receptors 1A and 2A during the kinetics of allergic contact dermatitis (ACD). Method Biopsies from 10 female nickel-allergic patients were obtained at 0, 6, 24, 48 and 72 h after nickel application using a patch testing procedure and then analysed by immunohistochemistry. Results Higher 5-HT epidermal immunoreactivity was seen at 0 and 6 h compared with 24, 48 and 72 h. The number of 5-HT labelled platelets was higher at 48 and 72 h compared with 0, 6 and 24 h. There was a decrease in the number of 5-HT1AR positive cells at 24, 48 and 72 h compared with 0 h. Furthermore, epidermal 5-HT1AR immunoreactivity was stronger at 48 and 72 h compared with 0 h. Total (dermis plus epidermis) number of 5-HT2AR positive cells was gradually increased in a time-dependent manner at 6, 24, 48 and 72 h compared with 0 h. Conclusions Our results suggest the implication of 5-HT, 5-HT1AR and 5-HT2AR in the development of human ACD and the possibility to target those receptors at an early stage of this inflammatory condition.

Original languageEnglish (US)
Pages (from-to)1200-1205
Number of pages6
JournalJournal of the European Academy of Dermatology and Venereology
Volume25
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • allergic contact dermatitis
  • inflammation
  • kinetics
  • receptor
  • serotonin

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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