Tinker where the tinkering's good

Matthew V. Rockman, David L. Stern

Research output: Contribution to journalShort surveypeer-review


Do general principles govern the genetic causes of phenotypic evolution? One promising idea is that mutations in cis-regulatory regions play a predominant role in phenotypic evolution because they can alter gene activity without causing pleiotropic effects. Recent evidence that revealed the genetic basis of pigmentation pattern evolution in Drosophila santomea supports this notion. Multiple mutations that disrupt an abdominal enhancer of the pleiotropic gene tan partly explain the reduced pigmentation observed in this species.

Original languageEnglish (US)
Pages (from-to)317-319
Number of pages3
JournalTrends in Genetics
Issue number7
StatePublished - Jul 2008

ASJC Scopus subject areas

  • Genetics


Dive into the research topics of 'Tinker where the tinkering's good'. Together they form a unique fingerprint.

Cite this