TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

Angela R. Kamer; Ronald G. Craig; Elizabeth Pirraglia; Ananda P. Dasanayake; Robert G. Norman; Robert J. Boylan; Andrea Nehorayoff; Lidia Glodzik; Miroslaw Brys; Mony J. de Leon

doi:10.1016/j.jneuroim.2009.08.013

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

Angela R. Kamer, Ronald G. Craig, Elizabeth Pirraglia, Ananda P. Dasanayake, Robert G. Norman, Robert J. Boylan, Andrea Nehorayoff, Lidia Glodzik, Miroslaw Brys, Mony J. de Leon

Research output: Contribution to journal › Article › peer-review

Abstract

The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-α and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-α classification of clinical AD and NL. This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.

Original language	English (US)
Pages (from-to)	92-97
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	216
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2009.08.013
State	Published - Nov 30 2009

Keywords

Alzheimer's disease
Biomarkers
Diagnosis
Inflammation
Periodontal antibodies
TNF-α

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2009.08.013

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@article{61a9563856814c5ba5f27fa12703a66a,

title = "TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects",

abstract = "The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-α and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-α classification of clinical AD and NL. This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.",

keywords = "Alzheimer's disease, Biomarkers, Diagnosis, Inflammation, Periodontal antibodies, TNF-α",

author = "Kamer, {Angela R.} and Craig, {Ronald G.} and Elizabeth Pirraglia and Dasanayake, {Ananda P.} and Norman, {Robert G.} and Boylan, {Robert J.} and Andrea Nehorayoff and Lidia Glodzik and Miroslaw Brys and {de Leon}, {Mony J.}",

note = "Funding Information: This study was supported by the following grants: NIH-NIA AG12101 , AG08051 , AG03051 and CRR MO1RR0096 , and NYUCD Fund R7173 .",

year = "2009",

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doi = "10.1016/j.jneuroim.2009.08.013",

language = "English (US)",

volume = "216",

pages = "92--97",

journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

AU - Kamer, Angela R.

AU - Craig, Ronald G.

AU - Pirraglia, Elizabeth

AU - Dasanayake, Ananda P.

AU - Norman, Robert G.

AU - Boylan, Robert J.

AU - Nehorayoff, Andrea

AU - Glodzik, Lidia

AU - Brys, Miroslaw

AU - de Leon, Mony J.

N1 - Funding Information: This study was supported by the following grants: NIH-NIA AG12101 , AG08051 , AG03051 and CRR MO1RR0096 , and NYUCD Fund R7173 .

PY - 2009/11/30

Y1 - 2009/11/30

N2 - The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-α and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-α classification of clinical AD and NL. This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.

AB - The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-α and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-α classification of clinical AD and NL. This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.

KW - Alzheimer's disease

KW - Biomarkers

KW - Diagnosis

KW - Inflammation

KW - Periodontal antibodies

KW - TNF-α

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U2 - 10.1016/j.jneuroim.2009.08.013

DO - 10.1016/j.jneuroim.2009.08.013

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AN - SCOPUS:71749104020

SN - 0165-5728

VL - 216

SP - 92

EP - 97

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

Abstract

Keywords

ASJC Scopus subject areas

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