TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

Angela R. Kamer, Ronald G. Craig, Elizabeth Pirraglia, Ananda P. Dasanayake, Robert G. Norman, Robert J. Boylan, Andrea Nehorayoff, Lidia Glodzik, Miroslaw Brys, Mony J. de Leon

Research output: Contribution to journalArticlepeer-review

Abstract

The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-α and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-α classification of clinical AD and NL. This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalJournal of Neuroimmunology
Volume216
Issue number1-2
DOIs
StatePublished - Nov 30 2009

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Diagnosis
  • Inflammation
  • Periodontal antibodies
  • TNF-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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