@article{0739b3c088cd43ddab1cf5782d6f157e,
title = "Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS",
abstract = "An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months.",
author = "Ferrante, {K. L.} and J. Shefner and H. Zhang and R. Betensky and M. O'Brien and H. Yu and M. Fantasia and J. Taft and Beal, {M. F.} and B. Traynor and K. Newhall and P. Donofrio and J. Caress and C. Ashburn and B. Freiberg and C. O'Neill and C. Paladenech and T. Walker and A. Pestronk and B. Abrams and J. Florence and R. Renna and J. Schierbecker and B. Malkus and M. Cudkowicz",
note = "Funding Information: The authors thank the Muscular Dystrophy Association for financial support of this study and the subjects who participated in the study. The authors thank Vitaline Formulas and Kaneka for donating the coenzyme Q10/vitamin E wafers and raw materials used in the trial. Funding Information: Supported by the Mallinckrodt General Clinical Research Center at Massachusetts General Hospital, grant number M01-RR-01066, National Center for Research Resources, NIH, as well as the General Clinical Research Centers at Wake Forest University School of Medicine and Washington University School of Medicine (M01-RR00036, M01-RR07122) and by the Muscular Dystrophy Association. ",
year = "2005",
month = dec,
doi = "10.1212/01.wnl.0000187070.35365.d7",
language = "English (US)",
volume = "65",
pages = "1834--1836",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "11",
}