Tomographic Imaging of BiologicalTissue by Time-Resolved, Model-Based, Iterative Image Reconstruction

Andreas Hielscher, Alexander D. Klose, David Catarious, Kenneth M. Hanson

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    Currently available tomographic image reconstruction schemes for photon migration tomography (PMT) are mostly based on the limiting assumptions of small perturbations and a priori knowledge of the optical properties of a reference medium. In this work a model- based iterative image reconstruction (MOBIIR) method is presented, which does not require the knowledge of a reference medium or that the encountered heterogeneities are small perturbations. After a description of the major code structure and a review of the mathematical background, the clinical relevant examples of brain imaging and breast cancer detection are discussed. It is shown that ventricular bleedings in the brain can be detected and that cysts and tumors in the breast can be distinguished using the MOBIIR technique.
    Original languageEnglish (US)
    Title of host publicationAdvances in Optical Imaging and Photon Migration, J. Fujimoto and M. Patterson, eds., Vol. 21 of OSA Trends in Optics and Photonics (Optica Publishing Group, 1998)
    StatePublished - 1998


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