Tooth Loss, Periodontal Disease, and Mild Cognitive Impairment Among Hispanic/Latino Immigrants: The Moderating Effects of Age at Immigration

Huabin Luo, Bei Wu, Hector M. González, Ariana Stickel, Linda M. Kaste, Wassim Tarraf, Martha L. Daviglus, Anne E. Sanders, Jianwen Cai

Research output: Contribution to journalArticlepeer-review


Background: The objectives were to assess (a) the association between poor oral health and mild cognitive impairment (MCI) in Hispanic/ Latino immigrants and (b) potential modification effects on this association by age at immigration. Methods: Data were from the Hispanic Community Health Study/Study of Latinos and its ancillary study—the Study of Latinos–Investigation of Neurocognitive Aging. MCI, a binary outcome variable, defined by the National Institute on Aging-Alzheimer’s Association criteria. The main exposure was significant tooth loss (STL), defined as a loss of 8 or more teeth, and periodontitis, classified using the Centers for Disease Control and Prevention and American Academy of Periodontology case classification. Multiple logistic regression was used to assess the association between STL/periodontitis and MCI and test moderation effects of age at immigration. The analytical sample comprised 5 709 Hispanic/Latino adult immigrants. Results: Hispanic/Latino immigrants with STL (adjusted odds ratio [AOR] = 1.36, 95% confidence interval [CI]: 1.01–1.85) were more likely to have MCI than those with greater tooth retention. Overall, migration to the United States after age 18 was associated with greater odds of MCI than migration at a younger age. A significant interaction effect between STL and age at immigration revealed that the effect of STL on MCI is even higher in those who immigrated to the United States at ages 35–49 years. Conclusions: STL is a significant risk factor for MCI and age at immigration had a modification effect on the association between STL and MCI. Better access to dental care, health education on risk factors of MCI, and promotion of good oral health may mitigate the burden of cognitive impairment in Hispanics/Latinos.

Original languageEnglish (US)
Pages (from-to)949-957
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number6
StatePublished - Jun 1 2023


  • Hispanics/Latinos
  • Immigrants
  • Mild cognitive impairment
  • Periodontal disease
  • Tooth loss

ASJC Scopus subject areas

  • General Medicine


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